Abstract: Impact toughness is a critical indicator for the engineering application of titanium alloys, yet it often exhibits a trade-off relationship with strength enhancement. To uncover the dominant factors governing high impact toughness while maintaining strength, a dataset comprising 188 samples of composition, heat treatment processes, and mechanical properties was compiled from publicly available literature. A three-layer ensemble model architecture centered on “expert models” was proposed. This architecture effectively addressed the problem of low accuracy of impact toughness prediction, mostly caused by mixed-type data training, and achieved a coefficient of determination of 0.88. Three dominant factors were identified based on SHAP values, the phase stability ratio (aluminum equivalent/molybdenum equivalent), Mo content, and phase stability ratio’s interaction effect with the average atomic radius. Quantitatively, a Mo content trap range (2~4) and two optimal design windows for the phase stability ratio and average atomic radius((2~3/1.35~1.40)×10⁻¹⁰ m, and (0~2/1.45~1.50)×10⁻¹⁰ m) were delineated. Literature validation based on a confusion matrix further verified the clear boundary of these dominant factors.