Abstract: In order to study the shock response behavior of PTFE/Al fragments under multiple impacts, experiments of reactive fragments impacting three-layer spaced aluminum targets were carried out and the shock response behavior was simulated using a numerical method including custom state equation. The spatial and temporal distribution of impact ignition and reaction behavior and damage effect of reactive fragment were quantitatively analyzed. Results show that reaction and spatial distribution of reactive fragments in numerical simulation is in good agreement with experimental results. The temporal distribution of reactive fragment reaction has a great influence on the damage effect of the middle plate. When middle plate thickness is 3.0 mm, reaction of reactive fragments mainly occurs in front of the middle plate. Perforation area and uplift range of the target increase with the increase of impact velocity, and uplift range is much larger than perforation area. When middle plate thickness is 1.5 mm and impact velocity is less than or equal to 1 100 m/s, reaction of reactive fragments mainly occurs behind the middle plate. As impact velocity increases to 1 300 m/s, main reaction position of reactive fragments is transferred to the front of the middle plate. With the increase of impact velocity, perforation area of middle plate increases first and then decreases, and uplift range increases continuously.