Abstract: The destructive effect of high blast load from strategic arms on the large complex warship structure was investigated based on the finite element method (FEM) simulations. Firstly, an actual geometrical model of an aircraft carrier structure was established, and the blast load was loaded through CONWEP method. And then, the dynamic response of warship structure was analyzed in detail, and the effects of several main factors were emphasized, including explosive equivalent and shock wave intensity, etc., on the damage mode of warship structure as well as the damage grade of deck. The results show that as the propagation distance of shock wave increases, the shock wave intensity decays exponentially along the flight deck surface, and it decays approximately linearly along different decks. Besides, with increasing the explosion equivalent and the shock wave intensity, the deformation or damage in the deck increases gradually, and the damage mode of warship structure changes from local plastic deformation to longitudinal strength mode, even the longitudinal residual strength mode would occur in the case of contact explosion. Moreover, in the condition of low explosion equivalent combined with shock wave intensity greater than 1.0 MPa, the flight deck, pod deck and hangar deck will fail gradually with the increase of shock wave intensity. In the case of medium explosion equivalent combined with shock wave intensity greater than 0.2 MPa, the flight deck and pod deck almost fail completely, and the function of hangar deck can be severely degraded. Comparatively, under the large explosion equivalent with shock wave intensity greater than 0.2 MPa, complete failure within local region will occur in all the three kinds of deck. Related investigation approach is beneficial to the damage evaluation of large complex warship structure under the high blast load in the engineering application.