Abstract: Blast-induced traumatic brain injury (bTBI) is a symbol injury in battle physic-cure area, and the injury mechanism is in leading strings. In order to find out the variation law of the space-time pressure field and the dynamic response characteristics of the brain when the blast waves interact with the head, a numerical simulation was carried out to analyze the process of blast wave acting on the head. Firstly, a three-dimensional finite element model with typical human head structure was established, and the validity of the finite element model was verified according to Nahum’s head impact experiments. And then, the simulation was carried out to analyze the impact process of blast waves on human head, concluding the variation law of the space-time pressure field with the interaction of blast waves and the head. Finally, the change of intracranial pressure of head was analyzed. The results show that, after the shock wave impacts on the head, the frontal and parietal lobe of the brain tissue pressure can appear high-frequency pressure cyclical fluctuations, and there will be a higher peak pressure to injure the damageable areas.