Abstract: In view of the protection requirements for the safe production and storage of flammable, explosive and other hazardous chemicals, three types of new reinforced concrete anti-blast structures with different configurations were designed to replace the traditional protective embankment, including straight, oblique and L-shaped types. Based on the self-developed high-precision large-scale simulation software with completely independent intellectual property rights, taking TNT explosive as example, the full-scale high-precision numerical simulation on the anti-explosion performance of three different structures was carried out. The results show that all new reinforced concrete anti-blast structure can effectively obstruct the explosive blast wave. The peak overpressure of shock wave decreases drastically, and the L-shaped reinforced concrete anti-blast structure can provide a better protection than the straight and oblique structures. The findings possess significance for guiding the design and construction of the new reinforced concrete anti blast structures.