Abstract: Several tests were carried out to study the toxicology of the preparation of compound nutrients, including acute toxicity test in mice, genetic toxicity test (Ames test, mice bone marrow cell micronucleus test and mice sperm abnormality test), and 30 days feeding test in rats. The preparation of compound nutrients was made mainly of lycopene and grape seed extract. The results show that, the MTD of the tested are more than 20 000 mg/kg BW, acute toxicity is no toxicity; the three genetic toxicity tests are all negative; in 30 days feeding test, each dose group rats grows well, blood indexes and histological examination etc. are no abnormal changes related to the sample. It can be concluded that the preparation of compound nutrients is safe under the test dose.