Abstract: In order to provide data for the validation of respiratory compensation method, a medical respiratory simulation platform with computer digital control was designed. In this paper, the fitting respiratory motion curve was mapped into three-dimensional coordinate data. Taking the ATmega2560 as the core, using the 42BYGH34 two-phase stepping motors, a three-dimensional motion platform was designed to simulate human respiratory movement. Firstly, the three-dimensional motion curve data sent from the host computer were analyzed by a single-chip microcomputer. And then the data were converted into a driving signal to drive the two-phase stepping motors with the driving chip, thereby drive the phantom on the fixture connected with the belt to do periodic motion, simulating the human body organ. The test results validate the stability and the reliability of the simulation platform. The simulation system can provide a platform for the collection of standard respiratory motion data.