Abstract: In order to directly observe the three-dimensional visualization results of volume data in three-dimensional space and perform contactless interaction, a volume rendering method was proposed to realize the aerial display and virtual interaction. Applying the aerial display and virtual interaction to the ray casting volume rendering algorithm, a system was designed for drawing aerial display and virtual interaction of volume data. The experimental results show that the medical image data can be displayed in the air well without relying on any display carrier, and the spatial reality is strong. Meanwhile, it can realize non-contact interaction through the sensory perception detection gesture. The interaction mode is flexible, natural and less limited to observer