Abstract: Transcranial magneto-acoustical electrical stimulation (TMAES) is a new noninvasive technique for brain nerve regulation, presenting a great application prospect. In this technique, the magneto-acoustic effect excited by the interaction of static magnetic field and ultrasonic wave was utilized to generate inductive current in nerve tissue and stimulate nerve tissue. Firstly, a synaptic connection GrC model was established based on cerebellar granular cell model (GrC model), and the action potential of the synaptic connection GrC model stimulated by TMAES was simulated to analyze the propagation direction of the action potential. Secondly, the different positions of neurons were stimulated by changing the synaptic connections of neurons, and the effects of TMAES on excitatory and inhibitory action potentials were compared. Finally, the effect of inhibition on neuronal firing patterns under TMAES was analyzed by changing the position of the inhibition points. The simulation results show that transcranial magnetic acoustic stimulation has an important influence on the firing rhythm of neurons in GrC model. The simulation of two neuron synaptic connection models under TMAES was carried out, which presents a great significance for further exploration and study of neuron conduction and connection modes.