Abstract: Due to the low structural strength and poor vibration isolation, the ground dry biochemical analyzer will suffer from damage and functional failure in the airborne working environment. A design method was proposed for the strength improvement and vibration isolation of dry biochemical analyzer, and verified by finite element analysis and mechanical tests. The results show that the strength safety margin can be more than 1.5, the vibration isolation efficiencies can be up to 56%, the performance index meets the quality control standard, and meets the requirements of aeromechanics after improvement.