Abstract: Based on the equivalent structure of real targets,the application of damage effectiveness evaluation of guided explosive bombs was studied. For infrared imaging and GPS guidance modes, the end ballistic characters were analyzed, and for designated power warhead, the relationship between the damage effectiveness and fuze explosion height and guidance precision was studied. From the simulation results, using the infrared image guidance mode, when the explosion height was increased, the explosion point was farther away from aiming point, it was harder for the fragments to hit the target;using GPS guidance mode, with the bomb embedded system, the explosion point could be adjusted to be just above the target, so the fragments could hit the target below and get better damage effect; so the damage effectiveness was not only related to warhead and fuze, but also related to guidance mode.From simulation analysis, the guidance mode has little effect on the dynamic power field of the warhead, so in the process of warhead research, in order to get the best warhead structure and explosion height, the guidancemode can be ignored and damage dimensionalities alone can be used to evaluate the warhead damage effectiveness.