Abstract: In order to study the impact of explosive shock wave on human body wearing a bullet-proof vest, the 2 and 3-dimensional numerical models of the blast wave impact on the bullet-proof vest were established. With the coupling of the Eulerian and Lagrangian grids, the forming explosion field due to the interaction between the shock wave and the bullet-proof vest was simulated. This research presented an analysis of the shock wave propagation process, including the reflection on the surface of the vest, the diffraction on the edge of the vest and the propagation process between the body and the bullet-proof vest. The simulation result indicates that the damage of shock wave on the human body is increased because of the interaction between the shock wave and the bullet-proof vest.