Abstract: A novel multi-channel electrode tissue impedance (MC-ETI) detection method was proposed to monitor the ambulatory electrocardiogram (AECG) and ETI signals. Without changing its input stage, this method can make the amplifier's input impedance remain enough high level by a low cost discrete circuit. To assess the performance of this method, twenty experiments in ten healthy volunteers were carried out. Simulation results show that the reference signal generated by MC-ETI has the strong correlation with MA in AECG (median=0.599). Comparing with single-channel electrode tissue impedance (SC-ETI) method, MC-ETI can achieve the same performance with a simple system.