Abstract: Acute toxicity test in mice,genetic toxicity test (Ames test,mice bone marrow cell micronucleus test and mice sperm abnormality test),and 30 days feeding test in rats were conducted to study the toxicology of the Chinese medicine health food.The Chinese medicine health food was made up of curcumae longae,ganoderma and other materials.The results showed that the MTD of the tested were more than 30 000 mg/kg BW,acute toxicity was no toxicity;the three genetic toxicity tests were all negative;in 30 days feeding test,each dose group rats grew well,blood routine indexes,blood biochemical indexes and histological examination etc.were no abnormal changes related to the sample.It was concluded that the Chinese medicine health food of curcumae longae and ganoderma was safe under the test dose.