Abstract: In order to fully tap various resources from network center cluster servers and edge nodes in cloud-P2P computing, that integrates cloud computing and peer-to-peer computing organically; to implement the data security and the remote data destruction in the cloud-P2P computing environment, after introducing the dynamic network edge nodes; furthermore, to prevent some malicious subjects with illegal tamper behaviors from uploading data, a defensive data destruction mechanism was proposed based on mobile agent for cloud-P2P systems. With the mechanism, the mobile agent can be used to detect data, the HASH values of the encrypted data can be put at the end of the ciphertext, and the data can be detected doubly at regular time, the normal data modification can be distinguished effectively from illegal tampering. The prediction of the attack possibility can be realized for related data, and the data, which have been or will be illegally tampered, can be deal with in time. A prototype system was designed and constructed based on the defensive data destruction mechanism. The experimental results show that the defensive data destruction mechanism based on mobile agent has the ideal performance in detection accuracy, safety and time cost.