Abstract: In this paper, the cyclosporine A and ethyl oleate were selected as model drug and enhancer respectively. A series of patches with different content of drug and/or enhancers were prepared. The positive electrets with different surface potentials were applied to the patches to study the relationships between polarization rules and patch parameters. The results show that the external electric field produced by electret can result in the polarization of the cyclosporine A patches. The polarization degree of the patch is proportional to the surface potential of the electret, but inversely proportional to the content of the drug as well as enhancer. The polarization degree caused by electret for different patches is in the following order:enhancer patches > drug patches > enhancer containing drug patches. Therefore, the external electric field of the electret can cause the polarization of the drug and enhancer which is favorable for the controllable transport and release of the drug.