Abstract: In order to solve the problem that vibration of vehicle-mount facility is too large to keep its performance in the running large freight vehicle, a facility-vehicle-road coupled model with 19 degrees of freedom was built based on Lagrange's principle. A time domain incentive model of random road was constructed by using a white noise-based model. And based on above two models, vibration of the facility on the vehicle was studied in different situations by time domain analysis method. And particle swarm optimization (PSO) was used to optimize related parameters. Results indicate that improving road level, choosing an appropriate speed, appropriately reducing the stiffness and damping of the facility's suspension can reduce the vibration of the facility and improve the large freight vehicle ride comfort. The research results provide a certain reference value to engineering problems.