Abstract: In order to get the dynamic response of the structure with acousitic tiles subjected to underwater explosion, the analytical method of fluid-structure interaction has been developed. Acoustic wave equation was adopted in the early of shock time at which the force is of very high frequency. By taking the propagation process of shock wave in the water, anechoic coating and steel layer as the research object. Impulse equivalency was used to modify the reflection coefficient of the shock wave in the Taylor's plate model. Next the effect of anechoic coating is mainly due to its mass, so the mass of coating was added on the corresponding nodes of finite model. Then combined with the DAA2 method, the computation method of fluid-structure interaction for the dynamic response was presented to analyze the dynamic response. The method decreases calculation scale greatly. Finally, tests of underwater explosion were carried out on stringer-stiffened cylinder covered with anechoic coating. The relative errors of accerleration amplitude, velocity amplitude and strain peak value are in 20%,10% and 15% compared to the test result, which verified the reliability of the calculation method.