Abstract: Baogan No.1(BGYH)is a preparation produced in Dai hospital, taken as a compound medicament to cure the liver trauma. There is a lot of demand in clinic application. Due to some problems of the Baogan No.1, i.e. moisture absorption of its powder, hardness of its grain production, big dosage, and so on characteristics restrict its more application in clinic. In this paper, the granule preparation procedure of Baogan No.1(BGYH)was optimized. According to pharmacopoeia, six pharmaceutic necessities were analyzed, including pharmaceutic necessity A, B, cornstarch, microlite fibrin, xylitol and amrita, to get the effects of different accession ratio of pharmaceutic necessities on the property of the prepared granule. A magnified test was taken to study the effect exactly. The results show that, when the component ratio of BGYH, pharmaceutical necessities A and B is 5:6:1, the property of granular preparation is better. And the critical relative humidity (CRH) of the granule prepared with this ratio is 69.66%. This means that the humidity should not exceed 69.66% in production and reserving. Some important data and theoretics are provided, and a batch of 125g granular preparation is produced for further research.