Abstract: According to the requirements of rapid detection and location of disease in clinical applications, the method of magnetic induction combining with electrical impedance detection was proposed in this paper, which has characteristics of no direct contact and high measurement efficiency using magnetic induction and large detection depth and accurate position using cryptographic and crossed resistance measurement. The integrated hardware design was established, including stable dual constant current source, cryptographic multiple detection mode, data acquisition in crossed planes and 3D image reconstruction. The electric conductivity, resolution, relative position error and sensitivity were analyzed by the composite electrical impedance imaging physical model, and the evaluation system with broad applications was formed consisting of accurate front-end collection and efficient image processing, which can satisfy the requirements with weak vital sign collection, real-time dynamic monitoring, rapid medical diagnosis as well as community health screening.