Abstract: Technological innovation is a necessary approach to solve the dilemma between economic development and environmental protection. In order to seek the optimal synergistic region of environmental regulation for industrial technology innovation,this paper took the panel data of 36 industrial sectors of large and medium-sized industrial enterprises in China from 2002 to 2015 as samples,constructed multi-stage analysis framework of environmental regulation on technological innovation's input and output,as well as empirically tested the nonlinear effects and multi-stage mechanisms of environmental regulation on technological innovation's input and output with distinguishing the heterogeneity of the fluctuation trend of pollution emission intensity by system GMM method. Further,it introduced the interaction models to analyze the interaction effects and synergies between environmental regulation,innovation's input and innovation's output,and comprehensively explored the collaborative mechanisms of environmental regulation on industrial technology innovation. The results showed that:(1)In the input stage,there was a"U-shaped",relationship between environmental regulation and technological innovation's input except in the sample of increasing pollution emission intensity;(2) In the output stage,environmental regulation and technological innovation's output showed an"inverted U-shaped" relationship;(3) Although there was an optimal synergetic interval of environmental regulation for collaborative innovation in the total sample,environmental regulation of industrial sectors were staying on the left of inflection point and much lower than the level of optimal synergetic interval;(4)environmental regulation and R&D investment intensity created synergistic effects on technological innovation's knowledge output at the stage of research and development; environmental regulation and technological innovation's knowledge output had synergistic effects on technological innovation's product output in the transformation phase. The overall environmental regulation of China's industries is still at a low level. To achieve a win-win situation for economy and environment,the government should increase the intensity of environmental regulation,establish differentiated and dynamically adjusted environmental regulation policies towards different industries,and promote technological innovation in industrial sectors effectively.