Abstract: In order to explore the influence of jet formation and penetration performance in multi-shape charge structures, caused by charge distance and detonation delay, finite element analysis was used to replicate jet formation and penetration test results under prototypical cases. The applicability of the modeling method, S-ALE algorithm, fluid-structure coupling algorithm, and material models and parameters were verified. On this basis, numerical simulation analyses were carried out at various charge distances and detonation delays. The interaction mechanism between adjacent charge structures, the propagation path of shock waves, the jet bending and formation parameters, penetration depth and diameter were analyzed. Furthermore, a mapping relationship between jet bending degree and penetration depth was established. The results show that the shock wave interactions between adjacent charges constitute the primary mechanism causing non-uniform pressure distribution across the liner surface, resulting in asymmetric jet formation. Charge interference has little effect on the jet formation and penetration performance of the first detonated charge (Jet-1), but has a significant impact on the jet of the latter detonated charge (Jet-2). There is a one-to-one correspondence between the charge distance and the detonation delay threshold. When charge distances are 0.25D, 0.5D, 0.75D, and 1.0D (D is the charge diameter), the detonation delay threshold is 4µs, 9µs, 14µs, and 20µs, respectively. When detonation delay is less than the threshold, jet formation and penetration performance of Jet-2 are less affected by interference. In contrast, when detonation delay is extended by 1µs and 2µs beyond the threshold, respectively, average jet bending degree under 3D stand-off distance increases to 0.076 and 0.171, and penetration depth decreases to 40.9% and 72.8%. Besides, by adding an explosion-proof plate between adjacent charge to reduce charge interference, the blast mitigation capabilities of three materials were quantitatively assessed, with 45# steel showing the best blast mitigation capability, followed by nylon and polyethylene materials.