Abstract: The realization of the goal of winning the fight against poverty cannot be achieved without the government’s full use of citizens’ personal information. The multiple attributes of “privacy”, “public”, “identifiable” and “liquidity” of personal information determine that it is the basic resource for achieving inclusive, holistic, and meticulous targeted poverty alleviation. In the different stages of precise identification, precise assistance and precise management, personal information plays a role in assisting initiation, motivation and guidance, and monitoring and evaluation. However, under the concept of prioritizing public interests, in the field of targeted poverty alleviation, it is very easy to tolerate the infringement of personal information rights and interests in order to achieve the goal of poverty alleviation. Objectively, it is faced with such practical difficulties as subject generalization, fuzzy boundary, anomie behavior and lack of procedures. In view of this, in targeted poverty alleviation, it is necessary to delimit the use of personal information to ensure the legitimacy and legality of the use of information, that is, to distinguish the subject of information use, determine the type of information that can be used, and form the principles, norms and procedural requirements for information use.